Soulforce members say they'll try to enter the school at noon Monday. The group says the school has policies that create a climate of discrimination against gays.
Soulforce's 2008 national bus tour of Southern faith-based colleges kicked off last week at Liberty University in Virginia.
Columbia International University spokesman Mike Blackwell said the school offered to meet with the group off campus, but the gay rights group declined.
Blackwell says the school won't invite groups on campus that advocate beliefs contrary to university policies and teachings.
Columbia International University's student handbook forbids homosexual behavior.