Madrid, Spain (Sports Network) - Defending champion Roger Federer was stunned by Japan's Kei Nishikori, while former titlist Rafael Nadal was an easy third-round winner Thursday at the $4.425 million Madrid Open, an ATP Masters event.
The 14th-seeded Nishikori knocked out the second-seeded former world No. 1 Federer, 6-4, 1-6, 6-2, in 1 hour, 35 minutes at The Magic Box.
The 23-year-old Nishikori notched two of his three service breaks in the deciding third set. Federer settled for only a pair of breaks on Day 5 and popped seven aces in a losing effort.
The 31-year-old Federer is a three-time Madrid champion and two-time runner-up who beat Czech Tomas Berdych in last year's finale.
The Swiss icon has yet to title anywhere in 2013.
Madrid lost its top seed on Tuesday when promising Bulgarian Grigor Dimitrov stunned Novak Djokovic.
Meanwhile, the fifth-seeded former No. 1 Nadal cruised past Russian veteran Mikhail Youzhny 6-2, 6-3 in 75 minutes on Day 5 on his beloved red clay.
The hot Nadal is now a dazzling 28-2 this season and seeking a fifth title in his seventh tournament. He titled in Barcelona two weeks ago, reaching a sixth final in six tries.
The reigning French Open king is a two-time Madrid titlist and two-time runner-up in the Spanish capital.
Last year's Madrid runner-up Berdych moved on with a 7-6 (7-5), 7-5 victory over big-serving South African Kevin Anderson, while seventh-seeded French star Jo-Wilfried Tsonga reached the round of eight with a come-from-behind 4-6, 6-3, 6-2 victory over Spanish southpaw Fernando Verdasco, and wild card Pablo Andujar was tied with fellow Spaniard Daniel Gimeno-Traver 5-5 in the first set when Gimeno-Traver retired from their bout.