Only two No. 1 seeds will be playing in the Sweet 16 of the NCAA tournament after Florida State knocked off Xavier 75-70 with a stunning comeback.
The upset by the ninth-seeded Seminoles comes two days after No. 16 seed Maryland-Baltimore County shocked No. 1 Virginia in the first round.
It's only the fourth time since the tournament expanded in 1984 that two No. 1 seeds failed to get out of the second round.
The Musketeers looked to be cruising with an 12-point lead midway through the second half before Florida State started slowly whittling it down. The lead was just two with five minutes left after a three-point play by Trent Forrest ended a 7-0 run for the Seminoles.
Phil Savoy's three-pointer with 1:07 remaining finally put Florida State ahead. A pair of free throws by Savoy made the lead three. Xavier's last gasp ended when Kerem Kanter air-balled a three-pointer with seven seconds left.
The victory was a measure of revenge for Florida State. The Seminoles were the No. 3 seed in last year's tournament, but were blown out by the 11th-seeded Musketeers in the second round.
Florida State will face Gonzaga in the Sweet 16 of the West Region.