CLEMSON, S.C. — (AP) — Trevor Lawrence threw three touchdown passes, two to Justyn Ross, and No. 2 Clemson answered any lingering questions from its close call at North Carolina, winning its 21st straight game by pounding Florida State 45-14 on Saturday.

The Tigers and coach Dabo Swinney faced two weeks of questions about why the defending national champions needed a last-minute stop on a 2-point conversion to escape the Tar Heels with a 21-20 win. Everything from Lawrence's health to Travis Etienne's fumble-itis (he had a key one to keep North Carolina in the game) came under scrutiny as many wondered: What's wrong with the Tigers?

Apparently, nothing.

Clemson (4-0 Atlantic Coast Conference) started 6-0 for a fifth straight year and beat the Seminoles (3-3, 2-2) for the fifth straight year, also a program best.

Lawrence completed 17 of 25 passes for 170 yards, including 10- and 8-yard TD throws to Ross. Lawrence also ran for a touchdown, the 6-foot-6 sophomore extending full body to get over the goal line.

Etienne ran for 127 yards and caught one of Lawrence's scoring throws.

"We all were challenged over the last two weeks to get back to being who we are," Clemson co-offensive coordinator Tony Elliott said.

Clemson coach Dabo Swinney pulled out everything he could to make this one a runaway. He had Etienne throw a 23-yard pass to Ross on the opening drive, then went for it on fourth-and-goal from Florida State 3 for Clemson's first touchdown, an inside pass from 3 yards out.

Swinney showed off this year's short-yardage Jumbo package on another fourth-and-short near the FSU goal line with starting defensive linemen Tyler Davis, Xavier Thomas and Nyles Pinckney in formation. But Thomas came up just shy of the touchdown.

Moments later when Clemson got the ball back on Chad Smith's interception with 40 seconds before the half and up 28-0, Lawrence threw twice into the end zone before B.T. Potter missed a 24-yard field goal try. Potter got an earful from an emphatic Swinney after the miss.

Florida State never had a chance in this one.

Quarterbacks James Blackman and Alex Hornibrook both threw first-half interceptions and the Seminoles managed only 63 yards in the first half. Things didn't get better after halftime as Blackman threw another pick that went for Derion Kendrick's 38-yard return score.

Florida State star Cam Akers' struggles against the Tigers continued. He had gained just 47 total yards vs. Clemson the past two games and ended with 34 yards on nine carries here.

The Seminoles broke the shutout with Blackman's 64-yard TD pass to Tamorrion Terry late in the third quarter.

"I told the guys this week we had to play at our best, but we didn't," Florida State coach Willie Taggart said. "Really disappointed."

Clemson won its 750th game, the 15th program nationally to do that and the first in the ACC.

THE TAKEAWAY

Florida State: The Seminoles hoped to carry momentum from two straight wins into Death Valley. Nope. The 'Noles don't have the experienced depth to challenge the four-time defending ACC champions. At least it was better than last year, when the Tigers won 59-10 in Tallahassee.

Clemson: Don't expect the "What's wrong?" questions to continue as the Tigers showed power and motivation to keep on top. Lawrence appeared healthy and confident in dismantling Florida State.

POLL IMPLICATIONS

Clemson should have no problem remaining No. 2 as it continues trying for a fifth consecutive College Football Playoff appearance.

UP NEXT

Florida State heads to No. 19 Wake Forest next Saturday night.

Clemson goes on the road to take on Louisville on Saturday.